MovDisordV3, Main, Exploration, bibRecord, 004618

Effects of a startle on heart rate in patients with multiple system atrophy

Identifieur interne : 004618 ( Main/Exploration ); précédent : 004617; suivant : 004619

Effects of a startle on heart rate in patients with multiple system atrophy

Auteurs : Josep Valls-Sole [Espagne] ; Misericordia Veciana [Espagne] ; Lucia Leon [Espagne] ; Francesc Valldeoriola [Espagne]

Source :

Movement disorders [ 0885-3185 ] ; 2002.

RBID : Pascal:02-0370892

Descripteurs français

Pascal (Inist)
- Atrophie multisystématisée, Rythme cardiaque, Contrôle cardiovasculaire, Système nerveux autonome, Sursaut, Stimulus acoustique, Electrocardiographie, Exploration, Méthode, Personne âgée.
Wicri :
- topic : Personne âgée.

English descriptors

KwdEn :
- Acoustic stimulus, Autonomic nervous system, Burst, Cardiovascular control, Elderly, Electrocardiography, Exploration, Heart rate, Method, Multiple system atrophy.

Abstract

The patient cooperation usually required for neurophysiological assessment of autonomic cardioregulatory function is difficult to obtain from patients with bradykinesia. A particularly interesting condition occurs in multiple system atrophy (MSA), which features both bradykinesia and autonomic dysfunction. Another characteristic of patients with MSA is their normal motor reaction to a startling stimulus. We used startle as a stimulus for testing autonomic cardioregulatory function in patients with MSA, thus avoiding the need for patient cooperation. In 10 healthy volunteers and 8 MSA patients, we recorded the electrocardiographic QRS complex with surface electrodes attached over the chest and delivered an acoustic startle stimulus after 8 seconds of baseline recording. We calculated the ratio between the pre-stimulus and the poststimulus heart beat intervals (R-R ratio) by dividing the mean prestimulus R-R interval by the shortest R-R interval obtained within 10 seconds poststimulus. Healthy volunteers had a significant shortening of the R-R interval. The peak of the effect occurred after 2 to 5 seconds, with a mean R-R ratio of 1.14 (S.D. = 0.09). In contrast, R-R shortening was markedly reduced in patients, even though they had a normal motor response. The mean R-R ratio in patients was 1.03 (S.D. = 0.03), significantly lower than in healthy volunteers (P < 0.01). Our results demonstrate an abnormally reduced modulation of the heart beat frequency in patients with MSA, compatible with a dysfunction on pathways responsible for autonomic regulation. The method described here may be useful in the assessment of cardioregulatory function in poorly cooperative patients with normal startle responses.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 002715
to stream PascalFrancis, to step Curation: 000606
to stream PascalFrancis, to step Checkpoint: 002778
to stream Main, to step Merge: 006817
to stream Main, to step Curation: 004618

Le document en format XML

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<front><div type="abstract" xml:lang="en">The patient cooperation usually required for neurophysiological assessment of autonomic cardioregulatory function is difficult to obtain from patients with bradykinesia. A particularly interesting condition occurs in multiple system atrophy (MSA), which features both bradykinesia and autonomic dysfunction. Another characteristic of patients with MSA is their normal motor reaction to a startling stimulus. We used startle as a stimulus for testing autonomic cardioregulatory function in patients with MSA, thus avoiding the need for patient cooperation. In 10 healthy volunteers and 8 MSA patients, we recorded the electrocardiographic QRS complex with surface electrodes attached over the chest and delivered an acoustic startle stimulus after 8 seconds of baseline recording. We calculated the ratio between the pre-stimulus and the poststimulus heart beat intervals (R-R ratio) by dividing the mean prestimulus R-R interval by the shortest R-R interval obtained within 10 seconds poststimulus. Healthy volunteers had a significant shortening of the R-R interval. The peak of the effect occurred after 2 to 5 seconds, with a mean R-R ratio of 1.14 (S.D. = 0.09). In contrast, R-R shortening was markedly reduced in patients, even though they had a normal motor response. The mean R-R ratio in patients was 1.03 (S.D. = 0.03), significantly lower than in healthy volunteers (P < 0.01). Our results demonstrate an abnormally reduced modulation of the heart beat frequency in patients with MSA, compatible with a dysfunction on pathways responsible for autonomic regulation. The method described here may be useful in the assessment of cardioregulatory function in poorly cooperative patients with normal startle responses.</div>
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	Movement Disorders (revue)
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Movement Disorders (revue)

Effects of a startle on heart rate in patients with multiple system atrophy

Effects of a startle on heart rate in patients with multiple system atrophy

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri